
5 Science-backed Supplements that can Eliminate Stress
April 23, 2025Berberine is a natural compound found in several plants. It has been used in traditional medicine for centuries due to its potential health benefits.
In this video, we will look at 5 benefits that you will experience when you take Berberine everyday for 30 days.
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1. Lowers blood sugar
Berberine helps lower blood sugar levels through a multifaceted mechanism that centers on the activation of AMP-activated protein kinase, AMPK.
Often referred to as the body’s metabolic master switch.
When berberine activates AMPK, cells increase their glucose uptake, particularly in skeletal muscle, allowing more sugar to be used for energy rather than accumulating in the bloodstream.
Simultaneously, this activation suppresses liver gluconeogenesis, the process where the liver produces new glucose, contributing significantly to lower overall blood sugar levels.
Additionally, berberine appears to enhance insulin sensitivity, meaning that the body’s cells can better respond to insulin and make efficient use of circulating glucose.
In one study, researchers looked at whether berberine could safely and effectively treat type 2 diabetes.
They divided the study into two parts. In the first part, 36 people who were newly diagnosed with diabetes received either berberine or metformin for three months, and both treatments were equally good at lowering blood sugar and triglyceride levels.
In the second part of the study, 48 patients with poorly controlled diabetes took berberine over a three‐month period. This treatment rapidly reduced fasting and post-meal blood sugar levels, improved overall glycemic control, lowered insulin levels, and even enhanced cholesterol numbers.
2. Improves Cognitive Health
Berberine can support your brain health.
By supporting improved blood flow to the brain, it ensures neurons receive the oxygen and nutrients they need to thrive.
Its potent antioxidant properties help combat oxidative stress, a major contributor to cognitive decline and aging.
Moreover, berberine is known to regulate inflammation, protecting delicate neural pathways from damage.
This remarkable compound also supports better energy metabolism in brain cells, contributing to sharper focus, clearer thinking, and a more resilient mind.
In one study, researchers examined whether berberine could help protect the brain from age-related memory problems.
They induced cognitive decline in mice by giving them D-galactose injections for 10 weeks and then tested their memory and learning using the Morris water maze.
The Morris water maze results showed that treatment with berberine significantly improved spatial learning and memory in mice with cognitive decline induced by D-gal.
The study also found that berberine changed levels of brain markers associated with aging.
3. Protects liver health
Berberine is shown to protect the liver. It supports liver function by reducing fat buildup, a common issue that can lead to fatty liver disease.
Its antioxidant properties work to combat oxidative stress, safeguarding liver cells from damage caused by toxins and free radicals.
Additionally, berberine helps regulate liver enzymes, ensuring they function within healthy ranges, and reduces inflammation, which can prevent the progression of liver-related conditions.
In one meta analysis and systematic review, researchers reviewed 10 randomized controlled trials involving 811 patients with non-alcoholic fatty liver disease to assess the efficacy and safety of berberine.
The study found that berberine significantly improved liver enzymes, lipid profile, and insulin sensitivity.
Overall, the analysis suggests that berberine may be an effective adjunct treatment for non-alcoholic fatty liver disease by enhancing liver function, lipid metabolism, and insulin sensitivity.
4. Improves Gut health
Berberine helps promote a balanced gut microbiome and supports overall digestive health.
It has antimicrobial properties that help combat harmful bacteria, allowing the beneficial microbes in your gut flora to thrive. This rebalancing of the microbiome is essential for optimal digestion and nutrient absorption.
Berberine also reduces inflammation in the gut lining, soothing discomfort and supporting better intestinal health.
By improving the gut barrier and regulating microbial populations, berberine fosters a healthier, more resilient digestive system that works in sync with your overall well-being.
In one study, researchers tested different doses of berberine in mice to see how it influences bile acid levels and gut bacteria.
Researchers measured bile acids, bile acid-related genes, and gut bacteria in the liver and blood, finding that berberine increased primary bile acids and decreased secondary bile acids in the blood with little effect on the liver.
Higher doses of berberine boosted enzymes and transporters for bile acid production and absorption, and also increased beneficial gut bacteria like Bacteroides.
Overall, the study suggests that berberine’s effects on bile acid levels and gut flora may help improve gut health.
5. Improves heart health
Berberine may support heart health by lowering cholesterol and reducing plaque buildup in the arteries, which can help decrease the risk of heart disease, heart attacks, and strokes.
In one study, researchers investigated the efficacy and safety of berberine for cardiovascular diseases. They did a systematic review and meta-analysis of 44 randomized controlled trials involving 4,606 patients.
The results showed that while berberine reduced stroke severity, inflammation markers and arterial thickness. When combined with statins, berberine was more effective in reducing total Cholesterol, triglycerides, LDL Cholesterol, and other key cardiovascular indicators.
Both berberine alone and in combination showed no significant adverse effects, suggesting its potential as a promising adjunct for CVD therapy, though further high-quality trials are needed to confirm these findings.
How to take Berberine Supplement
Berberine supplements should be taken with food. A daily dosage of 500 mg to 1500 mg is often recommended, depending on individual needs and desired effects.
As with any supplement, it’s crucial to consult with a healthcare professional before starting berberine supplementation, especially if you have any underlying health conditions or are taking other medications.
They can help determine the appropriate dosage and ensure it’s safe for you.